个人简介

刘红荣，湖南科技大学物理学本科，湘潭大学凝聚态物理博士，美国加州大学洛杉矶分校博士后，国家级高层次人才计划入选者，现任新·葡萄88805教授，博士生导师。主要从事软物质与生物物理领域研究，在冷冻电镜病毒近原子分辨三维重构、病毒对称失配及非对称重构领域做出了系列原创性成果。

Ｅmail: hrliu@hunnu.edu.cn hrliu2013@126.com

学术贡献：电子显微学及其应用；凝聚态物理中的交叉学科

教学情况：X射线与电子显微学；光学；计算物理；凝聚态物理前沿

承担课题：

1. 国家自然科学基金重点项目：冷冻电镜病毒非对称重构研究（12034006）.

2. 国家自然科学基金面上项目：冷冻电镜噬菌体对称失配重构研究（32071209）.

3. 湖南省自然科学基金创新研究群体项目：显微成像理论及生物应用（2019JJ1002）.

4. 国家重点研发计划课题：冷冻电镜原子分辨结构解析高效算法的开发与应用（2016YFA0501103）.

5. 国家自然科学基金重大研究计划（高性能科学计算的基础算法与可计算建模）集成项目：冷冻电镜三维重构的关键算法研究及其应用（91530321）.

6. 国家自然科学基金面上项目：基于冷冻电镜二十面体对称失配三维重构的腺病毒结构研究（31570742）.

7. 国家自然科学基金面上项目：双链RNA病毒甲基转移酶活性位点的空间定位—冷冻电镜原子分辨三维重构（31370736）.

8. 国家自然科学基金重大研究计划项目（高性能科学计算的基础算法与可计算建模）培育项目：基于球坐标系的冷冻电镜二十面体病毒高分辨三维重构的算法研究（91230116）.

9. 国家自然科学基金面上项目：最大熵方法在冷冻电镜单颗粒技术中的应用（31170706）.

10. 国家自科基金面上项目：冷冻电镜单颗粒技术中测定生物大分子颗粒取向的新算法研究（31070663）.

代表性论文：

1. Shuai Yuan, Jialing Wang, Dongjie Zhu, Nan Wang, Qiang Gao, Wenyuan Chen, Hao Tang, Junzhi Wang*, Xinzheng Zhang*, Hongrong Liu*, Zihe Rao*, andXiangxi Wang*, Cryo-EM structure of a Herpesvirus capsid at 3.1 Å,Science 2018, 360: eaao7283.

2. Hongrong Liu*，Lingpeng Cheng*，Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus,Science 2015, 349: 1347-1350.

3. Hongrong Liu，Lei Jin，Sok Boon S. Koh，Ivo Atanasov，Stan Schein，Lily Wu，Z Hong Zhou*. Atomic structure of human adenovirus by cryoEM reveals interactions among protein networks,Science 2010, 329: 1038-1043.

4. Hao Xiao#, Le Tan#, Zhixue Tan#, Yewei Zhang, Wenyuan Chen, Xiaowu Li, Jingdong Song*, Lingpeng Cheng*, and Hongrong Liu*, Structure of the siphophage neck-tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly,PLoS Biol 2023, 21: e3002441.

5. Zhen Han#, Wanjuan Yuan#, Hao Xiao, Li Wang, Junxia Zhang, Yuning Peng, Lingpeng Cheng*, Hongrong Liu*, and Li Huang*, Structural insights into a spindle-shaped archaeal virus with a seven-fold symmetrical tail,Proc Natl Acad Sci USA 2022, 119: e2119439119.

6. Wenyuan Chen#, Hao Xiao#, Li Wang#, Xurong Wang, Zhixue Tan, Zhen Han, Xiaowu Li, Fan Yang,Zhonghua Liu, Jingdong Song*, Hongrong Liu*, and Lingpeng Cheng*, Structural changes in bacteriophage T7 upon receptor-induced genome ejection,Proc Natl Acad Sci USA 2021, 118: e2102003118.

7. Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan Chen,Qingxiu Chen, Tao Yang, Jiawei Wang, Hongrong Liu*, Qin Fang*, Lingpeng Cheng*. Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly.Proc Natl Acad Sci USA 2018, 115: 7344-7349.

8. Jialing Wang, Shuai Yuan, Dongjie Zhu, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu*, Xinzheng Zhang*, Zihe Rao*, and Xiangxi Wang*. Structure of the herpes simplex virus type 2 Ccapsid with capsid-vertex-specific component.Nat Commun 2018, 9:3668.

9. Wenyuan Chen#, Hao Xiao#, Xurong Wang, Shuanglin Song, Zhen Han, Xiaowu Li, Fan Yang,Li Wang, Jingdong Song*, Hongrong Liu*,Lingpeng Cheng*. Structural changes of a bacteriophage upon DNA packaging and maturation,Protein Cell2020, 11(5):374–379.

10. Nan Wang#, Wenyuan Chen#, Ling Zhu#, Dongjie Zhu, Rui Feng, Jialing Wang, Bin Zhu, Xinzheng Zhang, Xiaoqing Chen, Xianjie Liu, Runbin Yan, Dongyao Ni, Grace Guoying Zhou, Hongrong Liu*, Zihe Rao*, Xiangxi Wang*. Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation,Protein Cell 2020, 11:366–373.

11. Jing Zheng#, Wenyuan Chen#, Hao Xiao, Fan Yang, Jingdong Song, Lingpeng Cheng*, and Hongrong Liu*,Asymmetric Structure of Podophage GP4 Reveals a Novel Architecture of Three Types of Tail Fibers,J Mol Biol 2023, 435: 168258

12. Xiaowu Li,Li Wang,Xurong Wang,Wenyuan Chen, Tao Yang,Jingdong Song*,Hongrong Liu*,LingpengCheng*, Structure of RdRps Within a Transcribing dsRNA Virus Provides Insights Into the Mechanisms of RNA Synthesis,J Mol Biol2020, 432: 358-366.

13. Xiaolong Li, Mingyang Jiang, Songjun Zeng*，and Hongrong Liu*,Polydopamine coated multifunctional lanthanide theranostic agent forvascular malformation and tumor vessel imaging beyond 1500 nm and imaging-guided photothermal therapy,Thranostics 2019, 9: 3866-3878.

14. Zhiming Deng, Xiaolong Li, Zhenluan Xue, Mingyang Jiang, Youbin Li, Songjun Zeng* and Hongrong Liu*，A high performance Sc-based nanoprobe for through-skull fluorescence imaging of brain vessels beyond 1500 nm，Nanoscale, 2018,10, 9393-9400.

15. Bin Zhu, Lingpeng Cheng*, Hongrong Liu*, Computing methods for icosahedral and symmetry-mismatch reconstruction of viruses by cryo-electron microscopy,Chin Phys B 2018, 27(5): 056802.

16. Xiaolong Li, Zhengluan Xue, Youbin Li, Songjun Zeng*, and Hongrong Liu*, Soft X-ray activated NaYF4:Gd/Tb scintillating nanorods for in vivo dual-modal X-ray/X-ray-induced optical bioimaging,Nanoscale 2017, 10(1): 342-350.

17. Xiaowu Li, Niyun Zhou, Wenyuan Chen, Bin Zhu, Xurong Wang, Bin Xu, Jiawei Wang, Hongrong Liu*, and Lingpeng Cheng*. Near-atomic resolution structure determination of a cypovirus capsid and polymerase complex using cryo-EM at 200 kV,J Mol Biol 2017, 429: 79-87.

18. Xiaowu Li, Hongrong Liu*, Lingpeng Cheng*, Symmetry-mismatch reconstruction of genomes and associated proteins within icosahedral viruses using cryo-EM,Biophys Rep 2016, 2: 25-32.

19. Bin Zhu, Chongwen Yang, Hongrong Liu*, Lingpeng Cheng*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, Ping Zhu,Identification of the Active Sites in the Methyltransferases of a Transcribing dsRNA Virus,J Mol Biol2014, 426: 2167-2174.

20. Changchun Cao, Xiaoyan Dong, Xiaobing Wu, Boyun Wen, Gang Ji, Lingpeng Cheng*, and Hongrong Liu*,Conserved fiber-penton base interaction revealed by a near-atomic resolution cryo-EM structure of adenovirus provides insight into receptor interaction,J Virol 2012, 86: 12322-12329.

21. Hongrong Liu, Lily Wu, Z Hong Zhou*. Model of the trimeric fiber of human adenovirus 5 and its interactions with the pentameric penton base by cryo-electron microscopy,J Mol Biol 2011,406: 764-774.

22. Hongrong Liu, Lingpeng Cheng, Songjun Zeng, Canying Cai Z. Hong Zhou, Qibin Yang*, Symmetry-adapted spherical harmonics method for high-resolution 3D single particle reconstructions,J Strul Boil 2008,161:64-73.

获奖情况

1. 湖南省自然科学奖一等奖：冷冻电镜三维重构算法研究与病毒原子结构解析（2022）

2. 湖南省先进工作者（2020）

3. 新·葡萄88805利君育人先锋奖（2018）

4. 第七届中国侨界贡献奖二等奖（2018）

5. 全省教育系统优秀共产党员（2016）

6. 湖南省优秀科技工作者（2016）