个人简介

从事软物质生物物理领域生物大分子结构和功能研究。

学位教育

1993/9－2000/7江西师范大学，物理学学士、光学硕士

2001/9－2004/4中山大学，生物物理学博士

工作经历

2000–2001 珠海亚力电子有限公司工程师

2004–2006 华南理工大学生物医学工程系讲师

2006–2007 University of Texas, Medical School at Houston博士后

2007–2009 California Nanosystem Institute, University of California, Los Angeles博士后

2009–2014 中国科学院生物物理研究所，副研究员，项目研究员

2014–2021 清华大学生命科学学院，研究系列教师，副研究员

2021–至今 新·葡萄88805，潇湘学者，教授

办公室：量子楼209

Ｅmail:lingpengcheng@hunnu.edu.cn

承担课题

1. 国家自然科学基金面上项目，32371263长尾科噬菌体受体识别、基因组释放和装配的分子机制研究，2024.01-2027.12，主持

2. 国家自然科学基金面上项目，31971122短尾科病毒对称失配衣壳的高分辨率结构和功能研究，2020/01-2023/12，主持

3. 国家重点研发计划，2016YFA0501100，高分辨率冷冻电镜新技术新方法的发展及在结构生物学中的应用，2016/07-2021/06，课题骨干

4. 国家自然科学基金面上项目，31570727，基于冷冻电镜的呼肠孤病毒转录的分子机制研究，2016/01-2019/12，主持

5. 国家自然科学基金面上项目，31170697，呼肠孤病毒的结构和功能研究，2012/01-2015/12，主持

6. 国家自然科学基金青年基金，31000333，病毒的冷冻电镜高分辨率三维重构研究，2011/01-2013/12，主持

7. 国家重点基础研究发展计划，2010CB912400，基于冷冻电子显微镜学的生物大分子的高时空分辨率的结构和功能研究，2010/01-2014/12，课题骨干

代表性论文

1. Hao Xiao, Le Tan, Zhixue Tan, Yewei Zhang, Wenyuan Chen, Xiaowu Li, Jingdong Song*,Lingpeng Cheng*, Hongrong Liu*, Structure of the siphophage neck–Tail complex suggests that conserved tail tip proteins facilitate receptor binding and tail assembly,PLOS Biology,Vol. 21,e3002441

2. Hao Xiao, Junquan Zhou, Fan Yang, Zheng Liu, Jingdong Song, Wenyuan Chen*, Hongrong Liu*, andLingpeng Cheng*. Assembly and Capsid Expansion Mechanism of Bacteriophage P22 Revealed by High-Resolution Cryo-EM Structures,Viruses, 2023, Vol. 15, 335.

3. Zhen Han, Wanjuan Yuan, Hao Xiao, Li Wang, Junxia Zhang, Yuning Peng,Lingpeng Cheng*, Hongrong Liu*, and Li Huang*.Structural insights into a spindle-shaped archaeal virus with a sevenfold symmetrical tail,Proceedings of the National Academy of Sciences, USA,2022, Vol. 119,e2119439119.

4. Hongrong Liu* andLingpeng Cheng*, Viral Capsid andPolymerase in Reoviridae.Subcellular Biochemistry99, Chapter 17, Springer, 2022

5. Jing Zheng, Wenyuan Cheng, Hao Xiao, Fan Yang, Xiaowu Li, Jingdong Song,Lingpeng Cheng*, and Hongrong Liu*.A capsid structure of ralstonia solanacearum podoviridae GP4 with a triangulation number T=9,Viruses, 2022, Vol. 14, 2431.

6. Wenyuan Chen, Hao Xiao, Li Wang, Xurong Wang, Zhixue Tan, Zhen Han, Xiaowu Li, Fan Yang, Zhonghua Liu, Jingdong Song*, Hongrong Liu*, andLingpeng Cheng*. Structural changes in bacteriophage T7 upon receptor-induced genome ejection,Proceedings of the National Academy of Sciences, USA,Vol. 118, (2021) e2102003118.

7. Wenyuan Chen, Hao Xiao, Xurong Wang, Shuanglin Song, Zhen Han, Xiaowu Li, Fan Yang, Li Wang, Jingdong Song*, Hongrong Liu*, andLingpeng Cheng*. Structural changes of a bacteriophage upon DNA packaging and maturation,Protein & Cell, 11 (2020): 374–379

8. Xiaowu Li, Li Wang, Xurong Wang, Wenyuan Chen, Tao Yang, Jingdong Song*, Hongrong Liu*, andLingpeng Cheng*.Structure of RdRps within a transcribing dsRNA virus provides insights into the mechanisms of RNA synthesis,Journal of Molecular Biology, 432 (2020):358-366

9. Xurong Wang, Fuxian Zhang, Rui Su, Xiaowu Li, Wenyuan Chen, Qingxiu Chen, Tao Yang, Jiawei Wang, Hongrong Liu*, Qin Fang*, andLingpeng Cheng*.Structure of RNA polymerase complex and genome within a dsRNA virus provides insights into the mechanisms of transcription and assembly,Proceedings of the National Academy of Sciences, USA,115 (2018): 7344-7349

10. Bin Zhu,Lingpeng Cheng*, Hongrong Liu*. Computing methods for icosahedral and symmetry-mismatch reconstruction of viruses by cryo-electron microscopyChinese Physics B27 (2018)

11. Xiaowu Li, Niyun Zhou, Wenyuan Chen, Bin Zhu, Xurong Wang, Bin Xu, Jiawei Wang, Hongrong Liu*,Lingpeng Cheng*.Near-atomic resolution structure determination of a cypovirus capsid and polymerase complex using cryo-EM at 200 kV,Journal of Molecular Biology.429 (2017): 79-87

12. Xiaowu Li, Hongrong Liu*,Lingpeng Cheng*. Symmetry-mismatch reconstruction of genomes and associated proteins within icosahedral viruses using cryo-EM,Biophysics Reports. 2016,2(1): 25-32

13. Hongrong Liu* andLingpeng Cheng*.Cryo-EM shows the polymerase structures and a nonspooled genome within a dsRNA virus,Science, Vol. 349, (2015), pp: 1347-1350

14. Bin Zhu, Chongwen Yang, Hongrong Liu*,Lingpeng Cheng*, Feng Song, Songjun Zeng, Xiaojun Huang, Gang Ji, and Ping Zhu, Identification of the active sites in the methyltransferases of a transcribing dsRNA virus,Journal of Molecular Biology,Vol. 26, (2014), pp: 2167-2174

15.Lingpeng Cheng, Xiaoxing Huang, Xiaomin Li, Wei Xiong, Wei Sun, Chongwen Yang, Kai Zhang, Ying Wang, Hongrong Liu, Xiaojun Huang, Gang Ji, Fei Sun, Congyi Zheng*, and Ping Zhu*, Cryo-EM structures of two bovine adenovirus type 3 intermediates,Virology. Vol. 450, (2014), pp: 174–181

16. Chongwen Yang, Gang Ji, Hongrong Liu, Kai Zhang, Guangqiao Liu, Fei Sun, Ping Zhu* andLingpeng Cheng*. Cryo-EM Structure of a transcribing cypovirus,Proceedings of the National Academy of Sciences, USA. Vol. 109, (2012), pp: 6118–6123

17. Changchun Cao, Xiaoyan Dong, Xiaobing Wu, Boyun Wen, Gang Ji,Lingpeng Cheng*, and Hongrong Liu*. Conserved fiber-penton base interaction revealed by a nearly atomic resolution cryo-EM structure of adenovirus provides insight into receptor interaction,Journal of Virology.Vol. 86, (2012), pp:12322-12329

18.Lingpeng Cheng, Jingchen Sun, Kai Zhang, Zongjun Mou, Xiaoxing Huang, Gang Ji, Fei Sun, Jingqiang Zhang*, and Ping Zhu*,Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping.Proceedings of the National Academy of Sciences, USA. Vol. 108, (2011), pp: 1373-1378

获奖情况

1. 2021年湖南省科学技术一等奖（冷冻电镜三维重构算法研究与病毒原子结构解析），排名第2。

2. 2010年教育部自然科学二等奖（病毒的电子显微学研究），排名第4。